Journal
NEURON
Volume 91, Issue 3, Pages 644-651Publisher
CELL PRESS
DOI: 10.1016/j.neuron.2016.06.036
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Funding
- Novartis Research Foundation
- ERC
- National Center of Competences in Research: SYNAPSY - The Synaptic Bases of Mental Diseases - Swiss National Science Foundation
- SNSF core grant
- EMBO
- Swiss National Science Foundation, Ambizione
- Canadian Institutes for Health Research
- Brain & Behaviour Research Foundation
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Cannabinoid receptor type 1 (CB1R)-expressing CCK interneurons are key regulators of cortical circuits. Here we report that retrograde endocannabinoid signaling and CB1R-mediated regulation of inhibitory synaptic transmission onto basal amygdala principal neurons strongly depend on principal neuron projection target. Projection-specific asymmetries in the regulation of local inhibitory microcircuits may contribute to the selective activation of distinct amygdala output pathways during behavioral changes.
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