Journal
CHEMICAL SOCIETY REVIEWS
Volume 44, Issue 17, Pages 6059-6093Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5cs00097a
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Funding
- DFG (International Research Training Group Selectivity in Chemo- and Biocatalysis-Seleca)
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Since its initial inception, the Conia-ene reaction, known as the intramolecular addition of enols to alkynes or alkenes, has experienced a tremendous development and appealing catalytic protocols have emerged. This review fathoms the underlying mechanistic principles rationalizing how substrate design, substrate activation, and the nature of the catalyst work hand in hand for the efficient synthesis of carbocycles and heterocycles at mild reaction conditions. Nowadays, Conia-ene reactions can be found as part of tandem reactions, and the road for asymmetric versions has already been paved. Based on their broad applicability, Conia-ene reactions have turned into a highly appreciated synthetic tool with impressive examples in natural product synthesis reported in recent years.
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