The (E)-2-(1,3-Diphenylallyl)-3,5-dimethoxyphenol

The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is described by means of the reaction of 3,5-dimethoxyphenol with (E)-1,3-diphenylprop-2-en-1-ol in 1,1,1,3,3,3-hexafluoroispropanol (HFIP), which acts as a solvent and reaction promoter. The reaction proceeds smoothly to afford the mentioned compound in high yield under a metal and additive-free procedure. The corresponding allylated phenol has been fully characterized.

Automated summary

The synthesis of (E)-2-(1,3-diphenylallyl)-3,5-dimethoxyphenol is achieved with high yield under a metal and additive-free procedure using 1,1,1,3,3,3-hexafluoroispropanol (HFIP) as a solvent and reaction promoter.