Journal
MOLBANK
Volume 2023, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/M1692
Keywords
pterin; alkyne; solubility; synthesis; crystal structure
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A new alkyne functionalized pterin derivative was successfully synthesized and its purity and chemical structure were confirmed through various methods. The compound can be further modified by utilizing its alkyne moiety and exhibits good solubility in solvents except for water.
A new alkyne functionalized pterin derivative was synthesized through a reaction of 7-chloropterin with propargyl alcohol in the presence of sodium hydride. The purity and chemical structure of the compound was validated by NMR (1H, 13C) spectroscopy, Mass (APCI source) spectrometry, elemental analysis, and X-ray crystallography. The title compound may be further functionalized by exploiting the yne moiety, for instance, using click chemistry. The novel pterin derivative, most notably, in contrast to typical pterin behavior, is now soluble or even well soluble in almost any solvent except water.
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