Journal
MOLBANK
Volume 2023, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/M1691
Keywords
pyrrolo[1,2-a]quinoxaline derivative; leukemia; antiproliferative activity
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A new substituted pyrroloquinoxaline compound was designed, synthesized, and characterized in this study. The compound showed interesting cytotoxic potential against different human leukemia cell lines.
(E)-Pyrrolo[1,2-a]quinoxalin-4-yl)-1-(3,4,5-trimethoxyphenyl)prop-2-en-1-one was designed then synthesized using a multi-step pathway starting from commercially available 2-nitroaniline. Structure characterization of this original substituted pyrrolo[1,2-a]quinoxaline compound was achieved by using FT-IR, H-1-NMR, C-13-NMR, X-Ray and HRMS spectral analysis. This new pyrroloquinoxaline shows interesting cytotoxic potential against different human leukemia cell lines (MV4-11, K562, MOLM14 and Jurkat cells).
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