Journal
NEUROMOLECULAR MEDICINE
Volume 19, Issue 1, Pages 1-10Publisher
HUMANA PRESS INC
DOI: 10.1007/s12017-016-8417-7
Keywords
mTOR; Parkinson's disease; Apoptosis; alpha-Synuclein; Oxidative stress
Categories
Funding
- National Natural Science Foundation of China [11375213, 21390411]
- Hundred Talents Program of the Chinese Academy of Sciences
Ask authors/readers for more resources
As a key regulator of cell metabolism and survival, mechanistic target of rapamycin (mTOR) emerges as a novel therapeutic target for Parkinson's disease (PD). A growing body of research indicates that restoring perturbed mTOR signaling in PD models can prevent neuronal cell death. Nevertheless, molecular mechanisms underlying mTOR-mediated effects in PD have not been fully understood yet. Here, we review recent progress in characterizing the association of mTOR signaling with PD risk factors and further discuss the potential roles of mTOR in PD.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available