Journal
CHEMICAL SENSES
Volume 40, Issue 7, Pages 453-459Publisher
OXFORD UNIV PRESS
DOI: 10.1093/chemse/bjv025
Keywords
ATP release; CALHM1; gustometer; pannexin 1; two-bottle choice test
Funding
- NEI NIH HHS [EY021517, R01 EY021517, R01 EY015537] Funding Source: Medline
- NIDCD NIH HHS [T32 DC000014, P30 DC011735, R01 DC012538, DC-12538] Funding Source: Medline
- NIDDK NIH HHS [DK-46791] Funding Source: Medline
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Taste compounds detected by G protein-coupled receptors on the apical surface of Type 2 taste cells initiate an intracellular molecular cascade culminating in the release of ATP. It has been suggested that this ATP release is accomplished by pannexin 1 (PANX1). However, we report here that PANX1 knockout mice do not differ from wild-type controls in response to representative taste solutions, measured using 5-s brief-access tests or 48-h two-bottle choice tests. This implies that PANX1 is unnecessary for taste detection and consequently that ATP release from Type 2 taste cells does not require PANX1.
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