Journal
NEUROLOGICAL SCIENCES
Volume 37, Issue 8, Pages 1277-1281Publisher
SPRINGER-VERLAG ITALIA SRL
DOI: 10.1007/s10072-016-2582-1
Keywords
Amyotrophic lateral sclerosis; Serum heat-shock proteins; Heat-shock protein 70; Heat-shock protein 90; Protein mis-folding
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Promotion Project of Education, Research, and Medical Care
- Grants-in-Aid for Scientific Research [25461274] Funding Source: KAKEN
Ask authors/readers for more resources
Heat-shock proteins (HSPs) have been implicated in the pathogenesis of amyotrophic lateral sclerosis (ALS). In this study, we aimed to examine whether the serum levels of HSPs (HSP27, HSP70, and HSP90) are altered in patients with ALS. We included 58 patients diagnosed with ALS and 85 control individuals. Serum HSP levels of patients and controls were determined using enzyme-linked immunosorbent assay. The serum levels of HSP70 and HSP90 were significantly higher in patients than in controls. In contrast, serum levels of HSP27 did not differ significantly between the patient and control groups. Moreover, serum levels of HSP70 and HSP90 in patients remained high throughout the duration of the disease. Taken together, our findings suggest that HSPs might have a role in ALS progression throughout the course of the disease. Further studies are needed to clarify the role of HSPs in the pathogenesis of ALS.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available