Journal
PHARMACIA
Volume 70, Issue 4, Pages 943-950Publisher
PENSOFT PUBLISHERS
DOI: 10.3897/pharmacia.70.e108879
Keywords
Ngu-Vi-Tieu-Khat; decoction; bioactivity; type-2 diabetes mellitus; traditional medicine
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This study assessed the hypoglycemic effects of NVTK decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The results showed that NVTK decoction improved diabetes symptoms, decreased insulin resistance, and had positive effects on pancreatic mass and blood lipid levels. The hypoglycemic effects of NVTK were comparable to those of gliclazide.
This study aims to assess the hypoglycemic effects of Ngu-Vi-Tieu-Khat (NVTK) decoction, a traditional Vietnamese medicine, in a rat model of type-2 diabetes. The NVTK decoction was prepared using the maceration method and tested for its hypoglycemic effects by measuring blood glucose levels, insulin resistance indicators, and pancreatic mass. The results showed that NVTK decoction improved diabetes symptoms, increased insulin levels, reduced insulin resistance, restored pancreatic mass, and decreased total cholesterol (TC), triglycerides (TG) and low-density lipoprotein cholesterol (LDL-C) while increasing high-density lipoprotein cholesterol (HDL-C). The hypoglycemic effects of NVTK were comparable to those of gliclazide at a dose of 10 mg/kg. In conclusion, NVTK decoction possesses hypoglycemic properties and could be explored as a potential traditional medicine for treating type-2 diabetes in humans.
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