Journal
NEUROLOGIC CLINICS
Volume 34, Issue 1, Pages 247-+Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.ncl.2015.08.011
Keywords
Mitochondrial; Neuropsychiatric; Behavioral; Autism; Depression; Anxiety; Bipolar disorder; Schizophrenia
Categories
Funding
- National Institutes of Health [NIH 2U54NS078059-04]
- Edison Pharmaceuticals
- Raptor Pharmaceuticals
- Stealth Peptides
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Mitochondrial diseases are a clinically heterogeneous group of disorders that ultimately result from dysfunction of the mitochondrial respiratory chain. There is some evidence to suggest that mitochondrial dysfunction plays a role in neuropsychiatric illness; however, the data are inconclusive. This article summarizes the available literature published in the area of neuropsychiatric manifestations in both children and adults with primary mitochondrial disease, with a focus on autism spectrum disorder in children and mood disorders and schizophrenia in adults.
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