Journal
NEUROIMAGE
Volume 133, Issue -, Pages 408-416Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2016.03.024
Keywords
Trait anxiety; State anxiety; Insula; Ventral medial prefrontal cortex; Test-retest study
Funding
- National Natural Science Foundation of China [31271087, 31470981, 31571137, 31500885, 61472330]
- National Outstanding young people plan
- Program for the Top Young Talents by Chongqing
- Fundamental Research Funds for the Central Universities [SWU1509383]
- Natural Science Foundation of Chongqing [cstc2015jcyjA10106]
- General Financial Grant from the China Postdoctoral Science Foundation [2015M572423]
- Special Funds from the Chongqing Postdoctoral Science Foundation [Xm2015037]
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Anxiety is a multidimensional construct that includes stable trait anxiety and momentary state anxiety, which have a combined effect on our mental and physical well-being. However, the relationship between intrinsic brain activity and the feeling of anxiety, particularly trait and state anxiety, remain unclear. In this study, we used resting-state functional magnetic resonance imaging (fMRI) (amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo)) to determine the effects of intrinsic brain activity on stable inter-individual trait anxiety and intra-individual state anxiety variability in a cross-sectional and test-retest study. We found that at both time points, the trait anxiety score was significantly associated with intrinsic brain activity (both the ALFF and ReHo) in the right ventral medial prefrontal cortex (vmPFC) and ALFF of the dorsal anterior cingulate cortex/anterior midcingulate cortex (dACC/aMCC). More importantly, the change in intrinsic brain activity in the right insula was predictive of intra-individual state anxiety variability over a 9-month interval. The test-retest nature of this study's design could provide an opportunity to distinguish between the intrinsic brain activity associated with state and trait anxiety. These results could deepen our understanding of anxiety from a neuroscientific perspective. (C) 2016 Elsevier Inc. All rights reserved.
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