Journal
NEUROIMAGE
Volume 127, Issue -, Pages 144-157Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.12.015
Keywords
Decision making; Hippocampus; Medial temporal lobe; Memory; Perirhinal cortex; Computational modeling
Funding
- NIH [F32-MH100904, R01-MH100121]
- NSF CAREER Award [1056019]
- Direct For Social, Behav & Economic Scie
- Division Of Behavioral and Cognitive Sci [1056019] Funding Source: National Science Foundation
Ask authors/readers for more resources
When faced with a new challenge, we often reflect on related past experiences to guide our behavior. The ability to retrieve memories that overlap with current experience, a process known as pattern completion, is theorized as a critical function of the hippocampus. Although this view has influenced research for decades, there is little empirical support for hippocampal pattern completion to individual memory elements and its influence on behavior. We used pattern analysis of brain activity measured with functional magnetic resonance imaging to demonstrate that specific elements of past experiences are reinstated in the hippocampus, as well as perirhinal cortex (PRC), when making decisions about those experiences. Linking neural measures of specific memory reinstatement in the hippocampus and PRC to behavior with computational modeling revealed that reinstatement predicts the speed of memory-based decisions. Moreover, hippocampal activation during retrieval was selectively coupled to regions of occipito-temporal cortex that showed content-specific item reinstatement. These results provide evidence for hippocampal pattern completion and its role in the mechanisms of decision making. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available