Journal
NEUROIMAGE
Volume 125, Issue -, Pages 556-570Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.10.025
Keywords
fMRI; Cortical layers; Dynamic causal modeling; Bayesian model comparison; Predictive coding
Funding
- Rene and Susanne Braginsky Foundation
- Clinical Research Priority Program (CRPP) Multiple Sclerosis of the University of Zurich
- Wellcome Trust [WT100092MA]
- Innovational Research Incentives Scheme of the Netherlands Organisation for Scientific Research
Ask authors/readers for more resources
High-resolution blood oxygen level dependent (BOLD) functional magnetic resonance imaging (fMRI) at the sub-millimeter scale has become feasible with recent advances in MR technology. In principle, this would enable the study of layered cortical circuits, one of the fundaments of cortical computation. However, the spatial layout of cortical blood supply may become an important confound at such high resolution. In particular, venous blood draining back to the cortical surface perpendicularly to the layered structure is expected to influence the measured responses in different layers. Here, we present an extension of a hemodynamic model commonly used for analyzing fMRI data (in dynamic causal models or biophysical network models) that accounts for such blood draining effects by coupling local hemodynamics across layers. We illustrate the properties of the model and its inversion by a series of simulations and show that it successfully captures layered fMRI data obtained during a simple visual experiment. We conclude that for future studies of the dynamics of layered neuronal circuits with high-resolution fMRI, it will be pivotal to include effects of blood draining, particularly when trying to infer on the layer-specific connections in cortex - a theme of key relevance for brain disorders like schizophrenia and for theories of brain function such as predictive coding. (C) 2015 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available