Journal
NEUROIMAGE
Volume 142, Issue -, Pages 533-543Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2016.08.021
Keywords
Hippocampus; Spatial navigation; MEG; Intracranial EEG; Source localization
Funding
- Zukunftskolleg of the University of Konstanz
- Deutsche Forschungsgemeinschaft DFG [DA 1485-1/1]
- ERA-Net NEURON via the Bundesministerium fur Bildung und Forschung BMBF [01EW1307]
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Human hippocampal theta oscillations play a key role in accurate spatial coding. Associative encoding involves similar hippocampal networks but, paradoxically, is also characterized by theta power decreases. Here, we investigated how theta activity relates to associative encoding of place contexts resulting in accurate navigation. Using MEG, we found that slow-theta (2-5 Hz) power negatively correlated with subsequent spatial accuracy for virtual contextual locations in posterior hippocampus and other cortical structures involved in spatial cognition. A rare opportunity to simultaneously record MEG and intracranial EEG in an epilepsy patient provided crucial in sights: during power decreases, slow-theta in right anterior hippocampus and left inferior frontal gyrus phaseled the left temporal cortex and predicted spatial accuracy. Our findings indicate that decreased slow-theta activity reflects local and long-range neural mechanisms that encode accurate spatial contexts, and strengthens the view that local suppression of low-frequency activity is essential for more efficient processing of detailed information. (C) 2016 Elsevier Inc. All rights reserved.
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