Journal
NEUROIMAGE
Volume 131, Issue -, Pages 42-47Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2015.11.039
Keywords
Environmental enrichment; Epigenetics; Histone-acetylation; Memory; Neurodegeneration; Alzheimer's disease
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There is substantial evidence that physical and cognitive exercise can enhance memory function in rodents as well as in humans. In addition various behaviors associated with physical activity have been associated with an increased cognitive reserve and a lower risk to develop age-associated memory decline and age-associated neurodegenerative diseases such as Alzheimer's disease. To better understand the molecular mechanisms that increase brain plasticity in response to exercise will therefore help to develop effective therapeutic strategies to treat memory decline. Here we review the currently available data with a specific focus on neurodegenerative diseases. (C) 2015 Published by Elsevier Inc.
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