Journal
NEUROIMAGE
Volume 132, Issue -, Pages 491-498Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.neuroimage.2016.02.073
Keywords
Vascular cortical model; Layer specific BOLD fMRI; Spatial specificity; Gradient echo; Spin echo
Funding
- Initial Training Network in High resolution Magnetic Resonance (HiMR) within the FP7 Marie Curie Actions of the European Commission [FP7-PEOPLE-2012-ITN-316716]
- ARC Future Fellowship [FT140100865]
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Blood oxygenation level dependent (BOLD) functional MRI has been used for inferring layer specific activation in humans. However, intracortical veins perpendicular to the cortical surface are suspected to degrade the laminar specificity as they drain blood from the microvasculature and BOLD signal is carried over from lower to upper cortical layers on its way to the pial surface. In this work, a vascular model of the cortex is developed to investigate the laminar specificity of the BOLD signal for Spin Echo (SE) and Gradient Echo (GE) following the integrative model presented by Uludag et al. (2009). The results of the simulation show that the laminar point spread function (PSF) of the BOLD signal presents similar features across all layers. The PSF for SE is highly localised whereas for GE there is a flat tail running to the pial surface, with amplitude less than a quarter of the response from the layer itself. Consequently the GE response at any layer will also contain a contribution accumulated from all lower layers. (C) 2016 Elsevier Inc. All rights reserved.
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