Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 29, Issue 5, Pages -Publisher
WILEY
DOI: 10.1111/nmo.12999
Keywords
autonomic nervous system; cholinergic anti-inflammatory pathway; vagal nerve stimulation
Funding
- National Institute for Health Research (NIHR) Enteric Health Technology Cooperative
- Medical Research Council [G0701706, G0300195, G0600965] Funding Source: researchfish
- MRC [G0701706, G0600965, G0300195] Funding Source: UKRI
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The vagus nerve is a central component of cholinergic anti-inflammatory pathways. We sought to evaluate the effect of bilateral transcutaneous cervical vagal nerve stimulation (t-VNS) on validated parameters of autonomic tone and cytokines in 20 healthy subjects. 24hours after t-VNS, there was an increase in cardiac vagal tone and a reduction in tumor necrosis factor-in comparison to baseline. No change was seen in blood pressure, cardiac sympathetic index or other cytokines. These preliminary data suggest that t-VNS exerts an autonomic and a subtle antitumor necrosis factor-effect, which warrants further evaluation in larger controlled studies.
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