Journal
NEUROGASTROENTEROLOGY AND MOTILITY
Volume 29, Issue 6, Pages -Publisher
WILEY
DOI: 10.1111/nmo.13004
Keywords
brain imaging; Cyclic Vomiting Syndrome; functional Magnetic Resonance; imaging; migraine
Funding
- National Institutes of Health [P01-AT006663, R01-AT007550, R01-AR064367, K23-DK069614, R21-AR057920]
- National Center for Research Resources [P41RR14075, CRC 1 UL1 RR025758]
- Norwegian Research Council/Marie Sklodowska-Curie Actions [FRICON/COFUND-240553/F20]
- Martinos Computing [S10RR023401, S10RR019307, S10RR019254, S10RR023043]
- International Foundation of Functional Gastrointestinal Disorders
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Cyclic Vomiting Syndrome (CVS) has been linked to episodic migraine, yet little is known about the precise brain-based mechanisms underpinning CVS, and whether these associated conditions share similar pathophysiology. We investigated the functional integrity of salience (SLN) and sensorimotor (SMN) intrinsic connectivity networks in CVS, migraine and healthy controls using brain functional Magnetic Resonance Imaging. CVS, relative to both migraine and controls, showed increased SLN connectivity to middle/posterior insula, a key brain region for nausea and viscerosensory processing. In contrast, this same region showed diminished SMN connectivity in both CVS and migraine. These results highlight both unique and potentially shared pathophysiology between these conditions, and suggest a potential target for therapeutics in future studies.
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