Journal
NEUROENDOCRINOLOGY
Volume 104, Issue 4, Pages 412-424Publisher
KARGER
DOI: 10.1159/000455233
Keywords
Polycystic ovary syndrome; Obesity; Hyperandrogenism; Insulin resistance; Cardiometabolic risks
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Polycystic ovary syndrome (PCOS) is a common and complex endocrinopathy with reproductive, metabolic, and psychological features and significantly increased cardiometabolic risks. PCOS is underpinned by inherent insulin resistance and hyperandrogenism. Obesity, more common in PCOS, plays an important role in the pathophysiology, exacerbating hyperinsulinaemia and hyperandrogenism, leading to recommended first-line lifestyle intervention. Significant traditional and non-traditional risk factors are implicated in PCOS in addition to obesity-exacerbated cardiometabolic risks and are explored in this review to promote the understanding of this common metabolic and reproductive condition. (C) 2016 S. Karger AG, Basel
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