Journal
CHEMICAL RESEARCH IN TOXICOLOGY
Volume 28, Issue 4, Pages 567-569Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.chemrestox.5b00021
Keywords
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Funding
- Research Grant Council of Hong Kong [ECS 609913]
- Hong Kong University of Science and Technology [R9310]
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Balkan endemic nephropathy (BEN) is a peculiar renal disease affecting thousands of farmers living in the suburban areas of the Balkan countries. Emerging evidence suggested that BEN is an environmental disease caused by chronic food poisoning with aristolochic acid (AA). We have developed a sensitive liquid chromatographytandem mass spectrometry method to detect urinary RNA-AA adducts. Results revealed high levels of RNA-AA adducts in the urine samples collected from AA-treated rats. To the best of our knowledge, this study is the first to report on the detection of urinary RNA-AA adducts. Compared with previous studies that quantified DNA-AA adducts, this method is more sensitive and user-friendly.
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