Journal
NEUROCHEMICAL RESEARCH
Volume 41, Issue 7, Pages 1806-1817Publisher
SPRINGER/PLENUM PUBLISHERS
DOI: 10.1007/s11064-016-1896-y
Keywords
Xanthones; Neuroprotection; Oxidative stress; Alzheimer's disease; Multifunction
Categories
Funding
- Guangdong Provincial International Cooperation Project of Science Technology [2013B051000038]
- National Natural Science Foundation of China [31371070]
- Fundamental Research Funds for the Central Universities [15ykjc08b]
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Natural xanthones have diversity pharmacological activities. Here, a series of xanthones isolated from the pericarps of Garcinia mangostana Linn, named alpha-Mangostin, 8-Deoxygartanin, Gartanin, Garciniafuran, Garcinone C, Garcinone D, and gamma-Mangostin were investigated. Biological screening performed in vitro and in Escherichia coli cells indicated that most of the xanthones exhibited significant inhibition of self-induced beta-amyloid (A beta) aggregation and also beta-site amyloid precursor protein-cleaving enzyme 1, acted as potential antioxidants and biometal chelators. Among these compounds, alpha-Mangostin, Gartanin, Garcinone C and gamma-Mangostin showed better antioxidant properties to scavenge Diphenyl-1-(2,4,6-trinitrophenyl) hydrazyl (DPPH) free radical th can Trolox, and potent neuroprotective effects against glutamate-induced HT22ell death partly by up-regulating HO-1 protein level and then scavenging reactive oxygen species. Moreover, Gartanin, Garcinone C and gamma-Mangostin could be able to penetrate the blood-brain barrier (BBB) in vitro. These findings suggest that the natural xanthones have multifunctional activities against Alzheimer's disease (AD) and could be promising compounds for the therapy of AD.
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