Journal
NEUROBIOLOGY OF LEARNING AND MEMORY
Volume 135, Issue -, Pages 146-151Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.nlm.2016.07.006
Keywords
Two-photon microscopy; Striatum; Basal ganglia; Deep brain imaging; Adeno-associated virus; In utero electroporation
Funding
- RIKEN
- JSPS KAKENHI [16K13109]
- Grants-in-Aid for Scientific Research [16K13109] Funding Source: KAKEN
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Imaging studies of the subcortical striatum in vivo have been technically challenging despite its functional importance in movement control and procedural learning. Here, we report a method for imaging striatal neuronal circuits in mice in vivo using two-photon microscopy. Cell bodies and intermingled dendrites of GABAergic neurons labeled with fluorescent proteins were imaged in the dorsal striatum through an imaging window implanted in the overlying cortex. This technique could be highly useful for studying the structure and function of striatal networks at cellular and subcellular resolutions in normal mice, as well as in mouse models of neurological disorders. (C) 2016 The Authors. Published by Elsevier Inc.
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