Journal
NEUROBIOLOGY OF AGING
Volume 47, Issue -, Pages 63-70Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.07.010
Keywords
Obesity; White-matter volume; Structural MRI; Population-based
Categories
Funding
- Bernard Wolfe Health Neuroscience Fund
- Wellcome Trust [RNAG/259]
- Biotechnology and Biological Sciences Research Council [BB/H008217/1]
- BBSRC [BB/H008217/1] Funding Source: UKRI
- MRC [MC_U105597119, MC_U105579215] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [BB/H008217/1] Funding Source: researchfish
- Medical Research Council [MC_U105597119, MC_U105579215, MC_UU_12012/5/B] Funding Source: researchfish
- National Institute for Health Research [NF-SI-0611-10084] Funding Source: researchfish
- Wellcome Trust [103838/Z/14/Z] Funding Source: researchfish
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Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neuro-degeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis of magnetic resonance image-based brain structure on a population-based cohort of healthy adults. Study participants were originally part of the Cambridge Centre for Ageing and Neuroscience (Cam-CAN) and included 527 individuals aged 20-87 years. Cortical reconstruction techniques were used to generate measures of whole-brain cerebral white-matter volume, cortical thickness, and surface area. Results indicated that cerebral white-matter volume in overweight and obese individuals was associated with a greater degree of atrophy, with maximal effects in middle-age corresponding to an estimated increase of brain age of 10 years. There were no similar body mass index-related changes in cortical parameters. This study suggests that at a population level, obesity may increase the risk of neurodegeneration. (C) 2016 The Authors. Published by Elsevier Inc.
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