Journal
NEUROBIOLOGY OF AGING
Volume 44, Issue -, Pages 127-137Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2016.05.002
Keywords
Caloric restriction; O-linked-N-acetylglucosamine; Calcium homeostasis; Learning impairment; Hippocampus
Categories
Funding
- Basic Science Research Program through the National Research Foundation of Korea [2014R1A2A1A11049588, 2015R1A5A2008833]
- National Research Foundation of Korea [2014R1A2A1A11049588] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Ask authors/readers for more resources
Diabetes may adversely affect cognitive function and, conversely, caloric restriction (CR) increases longevity and improves memory. To shed light on the unknown underlying mechanisms involved in these observations, we examined the effects of CR on serum metabolic parameters and hippocampal protein expression in the ob/ob mice model of obesity-induced diabetes. We found that CR reduced hepatic steatosis and insulin resistance in ob/ob mice. In addition, CR increased the levels of hippocampal O-linked-N-acetylglucosamine (O-GlcNAc) and GlcNAc transferase and decreased the expression of calcium/calmodulinedependent protein kinase II, lipocalin-2, and phosphorylated tau. Furthermore, CR lessened the learning deficits that are typically seen in ob/ob mice. These findings indicate that CR may reverse obesity-related brain glucose impairment and intracellular Ca2+ dysfunction and relieve learning impairment associated with diabetes. (C) 2016 Elsevier Inc. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available