Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 11, Pages 2447-2452Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500044
Keywords
decarboxylative coupling; metal-free; annulations; N-propargyl heterocycles; three-component reaction
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Funding
- Shanghai Municipal Education Commission [14ZZ159]
- Shanghai Municipal Science and Technology Commission [12430501300]
- Shanghai Natural Science Foundation [15ZR1418800]
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A three-component reaction of a 1,2-amino alcohol or 1,3-amino alcohol with a formaldehyde solution and a propiolic acid was developed and studied. This new strategy provided an efficient access to biologically and synthetically important N-propargyl oxazolidines, 1,3-oxazinanes and thiazolidine bearing a diverse range of substituents in good yields. The transformation involves a cascade process that begins with an annulation and is followed by the metal-free decarboxylative coupling.
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