A rare association of neuromyelitis optica, antisynthetase, and antiphospholipid syndrome

Review Immunology

Neuromyelitis optica spectrum disorders: from pathophysiology to therapeutic strategies

Edgar Carnero Contentti et al.

Summary: Neuromyelitis optica (NMO) is a chronic inflammatory autoimmune disease characterized by acute optic neuritis and transverse myelitis. It is caused by a pathogenic serum IgG antibody targeting the water channel aquaporin 4 (AQP4). Recent studies have shown significant progress in identifying new treatments for NMOSD.

JOURNAL OF NEUROINFLAMMATION (2021)

Add to Collection

Review Clinical Neurology

Neuromyelitis optica spectrum disorders

Shabeer Paul et al.

Summary: Over the past two decades, the disease concept of NMOSD has significantly changed with the detection of MOG antibody and the understanding of immune astrocytopathy. The revised diagnostic criteria have widened the clinical spectrum of NMOSD, allowing for earlier diagnosis and prompt initiation of effective immunosuppression for better long-term outcomes. Challenges still remain in treating seronegative NMOSD due to limited treatment options.

JOURNAL OF THE NEUROLOGICAL SCIENCES (2021)

Add to Collection

Review Rheumatology