Journal
NEURAL REGENERATION RESEARCH
Volume 11, Issue 6, Pages 1015-1024Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.184506
Keywords
nerve regeneration; ischemia/reperfusion injury; animal model; mechanisms of action; clinical application; research progress; genetic modification; angiogenesis; replacement therapy; neural regeneration
Categories
Funding
- Natural Science Foundation of Heilongjiang Province of China [H2015083]
- Higher Education Reform Project of Mudanjaing Medical University of China [2013016]
Ask authors/readers for more resources
Animal and clinical studies have confirmed the therapeutic effect of bone marrow mesenchymal stem cells on cerebral ischemia, but their mechanisms of action remain poorly understood. Here, we summarize the transplantation approaches, directional migration, differentiation, replacement, neural circuit reconstruction, angiogenesis, neurotrophic factor secretion, apoptosis, immunomodulation, multiple mechanisms of action, and optimization strategies for bone marrow mesenchymal stem cells in the treatment of ischemic stroke. We also explore the safety of bone marrow mesenchymal stem cell transplantation and conclude that bone marrow mesenchymal stem cell transplantation is an important direction for future treatment of cerebral ischemia. Determining the optimal timing and dose for the transplantation are important directions for future research.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available