Journal
NEURAL REGENERATION RESEARCH
Volume 11, Issue 8, Pages 1220-1223Publisher
MEDKNOW PUBLICATIONS & MEDIA PVT LTD
DOI: 10.4103/1673-5374.189168
Keywords
volume transmission; receptor-receptor interaction; heteroreceptor complexes; oligomerization; brain communication; learning; memory; central monoamine neurons
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Funding
- Swedish Medical Research Council [04X-715]
- AFA Forsakring [130328]
- Hjarnfonden
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The discovery of the central monoamine neurons not only demonstrated novel types of brain stem neurons forming global terminal networks all over the brain and the spinal cord, but also to a novel type of communication called volume transmission. It is a major mode of communication in the central nervous system that takes places in the extracellular fluid and the cerebral spinal fluid through diffusion and flow of molecules, like neurotransmitters and extracellular vesicles. The integration of synaptic and volume transmission takes place through allosteric receptor-receptor interactions in heteroreceptor complexes. These heterocomplexes represent major integrator centres in the plasma membrane and their protomers act as moonlighting proteins undergoing dynamic changes and their structure and function. In fact, we propose that the molecular bases of learning and memory can be based on the reorganization of multiples homo and heteroreceptor complexes into novel assembles in the post-junctional membranes of synapses.
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