Journal
HELIYON
Volume 9, Issue 10, Pages -Publisher
CELL PRESS
DOI: 10.1016/j.heliyon.2023.e20564
Keywords
Coronavirus disease 2019; Vaccination; Sudden death; cardiomyopathy; Autopsy case series
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In this study, the autopsy findings of two cases of sudden death due to COVID-19-related cardiomyopathies were reported. The study found common pathological findings in both hearts, which included decreased staining intensity, loss of rhabdomeres, and multivacuolation in cardiomyocytes. These findings could aid in diagnosing sudden death due to COVID-19-related cardiomyopathy, even when standard staining techniques show few findings.
Background: Cardiomyopathy is a leading cause of sudden out-of-hospital death after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and coronavirus disease 2019 (COVID-19) vaccination. Such unexpected COVID-19-related cardiomyopathies are challenging to diagnose as specific pathological findings are not always identified.Case summary: We reported the autopsy findings of two cases of sudden death due to COVID-19related cardiomyopathies. In one case, death occurred after SARS-CoV-2 infection, while in the other, after COVID-19 vaccination. We found common pathological findings in both hearts: decreased staining intensity with special stains, loss of rhabdomeres, and multivacuolation in cardiomyocytes without inflammatory cell infiltration. The remaining organs showed no findings that could have contributed to the deaths.Conclusion: In cases of sudden death after SARS-CoV-2 infection or COVID-19 vaccination, the decreased staining intensity with special stains may aid the diagnosis of sudden death due to COVID-19-related cardiomyopathy, even when H&E staining shows few findings.
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