Abscisic acid ameliorates motor disabilities in 6-OHDA-induced mice model of Parkinson's disease

Parkinson's disease (PD) is characterized by a myriad of symptoms, encompassing both motor disabilities and cognitive impairments. Recent research has shown that abscisic acid (ABA) is a phytohormone found in various brain regions of several mammals and exhibits neuroprotective properties. To investigate the effects of ABA on cognitive and motor disorders, a mouse model of PD was utilized. The administration of 6-hydroxydopamine (6-OHDA) to the lateral ventricles was conducted, with ABA (10 and 15 & mu;g/mouse, i. c.v.) being administered for one week after the 6OHDA injection for 4 days. Motor and cognitive performance were evaluated through the use of open field, rotarod, wire grip, and shuttle box tests. The results indicated that cognitive function and motor disorders were significantly impaired in 6-OHDA-treated animals. However, in mice treated with 6-OHDA, ABA (15 & mu;g/mouse) significantly reversed balance and muscle strength deficits. It should be noted that the administration of ABA did not significantly improve cognitive impairment or rearing in Parkinsonism mice. Therefore, the findings suggest that ABA plays a crucial role in protecting mice from motor disabilities caused by 6-OHDA.

Automated summary

Parkinson's disease is characterized by motor disabilities and cognitive impairments. Abscisic acid (ABA) has been found in various brain regions of mammals and has neuroprotective properties. A mouse model of PD was used to investigate the effects of ABA on motor and cognitive disorders. The results showed that ABA significantly improved balance and muscle strength deficits caused by 6-OHDA, but did not improve cognitive impairment or rearing in Parkinsonism mice.