Niosomes in cancer treatment: A focus on curcumin encapsulation

Curcumin is widely used as a therapeutic drug for cancer treatment. However, its limited absorption and rapid excretion are the major therapeutic limitations to its clinical use. Using niosomes as a curcumin delivery system is a cheap, easy, and less toxic strategy for enhancing the absorption of curcumin by cells and delaying its excretion. Thus, there is a vital need to explore curcumin niosomes to configure the curcumin to suitably serve and aid current pharmacokinetics in treatments for cancer. To date, no comprehensive review has focused on the cytotoxic effects of curcumin niosomes on malignant cells. Thus, this review provides a critical analysis of the curcumin niosomes in cancer treatment, formulations of curcumin niosomes, characterizations of curcumin niosomes, and factors influencing their performance. The findings from this review article can strongly accelerate the understanding of curcumin niosomes and pave a brighter direction towards advances in the pharmaceutical, biotechnology, and medical industries.

Automated summary

Curcumin is widely used for cancer treatment, but its limited absorption and rapid excretion hinder its clinical use. Niosomes as a delivery system for curcumin can enhance its absorption and prolong its excretion, providing a potential solution. This review analyzes the cytotoxic effects, formulations, characterizations, and performance factors of curcumin niosomes, aiming to accelerate advances in the pharmaceutical, biotechnology, and medical industries.