4.7 Article

Copper-Catalyzed Aryltrifluoromethylation of N-Phenylcinnamamides: Access to Trifluoromethylated 3,4-Dihydroquinolin-2(1H)-ones

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 11, Pages 2464-2468

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500261

Keywords

aryltrifluoromethylation; copper; diastereoselectivity; regioselectivity; Togni's reagent

Funding

  1. National Natural Science Foundation of China [21132003, 21421062, 21372131]
  2. Specialized Research Fund for the Doctoral Program of Higher Education [20130031110017]
  3. 111 Project of Ministry of Education of China [B06005]

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A method for copper-catalyzed aryltrifluoromethylation of N-phenylcinnamamides is reported. This method provides a straightforward route to a variety of CF3-containing 3,4-dihydroquinolin-2(1H)-ones with excellent regioselectivity and diastereoselectivity.

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