Journal
FERMENTATION-BASEL
Volume 9, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/fermentation9110924
Keywords
blasticidin; genome; lankacidin; lankamycin; nonribosomal peptide; polyketide; secondary metabolite; Streptomyces
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Streptomyces cellostaticus is a potential source of diverse polyketides and nonribosomal peptides, as revealed by the sequencing of its whole genome and survey of PKS and NRPS gene clusters. The genome of S. cellostaticus encoded multiple PKS and NRPS gene clusters, with annotated products including known and unknown secondary metabolites.
Polyketides and nonribosomal peptides are major secondary metabolites in members of the genus Streptomyces. Streptomyces cellostaticus is a validly recognized species and the type strain produces cellostatin. However, little is known about whether it has the potential to produce diverse polyketides and nonribosomal peptides. Here, we sequenced the whole genome of S. cellostaticus NBRC 12849(T) and surveyed polyketide synthase (PKS) and nonribosomal peptide synthetase (NRPS) gene clusters in the genome. The genome encoded 12 PKS, one NRPS and eight hybrid PKS/NRPS gene clusters. Among the 21 gene clusters, products of 10 gene clusters were annotated to be an annimycin congener, fuelimycins, lankamycin, streptovaricin, spore pigment, flaviolin, foxicin, blasticidin, lankacidin and an incarnatapeptine congener via our bioinformatic analysis. Although the other clusters were orphan and their products were unknown, five of them were predicted to be compounds derived from two independent diketides, a tridecaketide, a triketide and a tetraketide with a cysteine residue, respectively. These results suggest that S. cellostaticus is a source of diverse polyketides and hybrid polyketide/nonribosomal peptides, including unknown and new secondary metabolites.
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