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NATURE METABOLISM
Volume -, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s42255-023-00895-8
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This study reveals the importance of dietary proline in maintaining gut health, as it modulates the metabolism and cytokine production of group 3 innate lymphoid cells (ILC3s) responsible for intestinal barrier integrity.
Group 3 innate lymphoid cells (ILC3s) maintain intestinal barrier integrity and nutrient absorption via IL-22; however, little is known about how these immune cells fuel effector function. Wu et al. now report that uptake of dietary proline acts as a critical metabolic modulator of the ILC3 transcriptome and cytokine production to maintain gut health.
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