Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 23, Issue 5, Pages 369-377Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb.3208
Keywords
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Funding
- Stowers Institute for Medical Research
- American Cancer Society [118857-RP-05-086-06-COUN]
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The synaptonemal complex (SC) is a meiosis-specific scaffold that links homologous chromosomes from end to end during meiotic prophase and is required for the formation of meiotic crossovers. Assembly of SC components is regulated by a combination of associated nonstructural proteins and post-translational modifications, such as SUMOylation, which together coordinate the timing between homologous chromosome pairing, double-strand-break formation and recombination. In addition, transcriptional and translational control mechanisms ensure the timely disassembly of the SC after crossover resolution and before chromosome segregation at anaphase I.
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