HLA-B27 status and inflammatory MRI lesions of the sacroiliac joints: a post hoc analysis in patients without axial spondyloarthritis

Article Rheumatology

Anatomical variation of the sacroiliac joint carries an increased risk for erosion and bone marrow oedema in axial spondyloarthritis

Katharina Ziegeler et al.

Summary: Joint shape variations are associated with inflammatory lesions on SI joint MRIs in axSpA patients. This should be taken into consideration in future research on the interplay of mechanical strain and inflammation in axSpA.

RHEUMATOLOGY (2023)

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Article Rheumatology

Keep an Eye on the Back: Spondyloarthritis in Patients With Acute Anterior Uveitis

Judith Rademacher et al.

Summary: This study aims to analyze the prevalence of spondyloarthritis (SpA) in patients with acute anterior uveitis (AAU), identify parameters associated with SpA, and evaluate referral algorithms for identifying patients with a high probability of having SpA. The study found a high prevalence of SpA in AAU patients, with the majority having predominantly axial SpA. Psoriasis, HLA-B27 positivity, elevated C-reactive protein level, and male sex were associated with the presence of SpA. The Dublin Uveitis Evaluation Tool (DUET) showed higher specificity than the Assessment of SpondyloArthritis international Society (ASAS) tool, but both strategies missed over 20% of AAU patients with SpA.

ARTHRITIS & RHEUMATOLOGY (2023)

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Article Rheumatology

POS0921 INFLUENCE OF HLA-B27 STATUS ON MR IMAGING FINDINGS IN PATIENTS WITH LOW BACK PAIN

S. T. Ulas et al.

ANNALS OF THE RHEUMATIC DISEASES (2023)

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Article Rheumatology

HLA-B27 as a predictor of effectiveness of treatment with TNF inhibitors in axial spondyloarthritis: data from the Swiss Clinical Quality Management Registry

Fabienne Froehlich et al.

Summary: This study aimed to investigate the impact of HLA-B27 on TNFi effectiveness in axSpA patients. The results showed that HLA-B27 negative patients had a higher risk of drug discontinuation in TNFi treatment, while male sex and elevated CRP levels were associated with longer drug retention. Therefore, HLA-B27 genotype is an important predictor of treatment effectiveness, while male sex and CRP levels may better describe the variability of response in individual patients.

CLINICAL RHEUMATOLOGY (2023)

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Article Rheumatology

Progressive Increase in Sacroiliac Joint and Spinal Lesions Detected on Magnetic Resonance Imaging in Healthy Individuals in Relation to Age

Thomas Renson et al.

Summary: This study reveals the frequent occurrence of spontaneous sacroiliac joint lesions in healthy individuals, especially in older age groups. These findings have important implications for the interpretation of MRIs in patients suspected of having spondyloarthritis.

ARTHRITIS & RHEUMATOLOGY (2022)

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Article Rheumatology

Presence of spondyloarthritis associated to higher disease activity and HLA-B27 positivity in patients with early Crohn's disease: Clinical and MRI results from a prospective inception cohort

Valeria Rios Rodriguez et al.

Summary: This study aimed to determine the prevalence of spondyloarthritis (SpA) and its associated factors in Crohn's disease (CD) patients undergoing systematic rheumatological and imaging assessments. The results showed that the prevalence of SpA in CD patients was approximately 19.4%, and it was associated with HLA-B27 expression and the clinical activity of CD.

JOINT BONE SPINE (2022)

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Article Rheumatology

Striking sex differences in magnetic resonance imaging findings in the sacroiliac joints in the population

J. Braun et al.

Summary: In patients with axial spondyloarthritis (axSpA), sex-specific differences were found in the extent of sacroiliac joint (SIJ) bone marrow edema (BME) with HLA-B27 being relevant only in males and postpartum state being important in females. This finding may have implications for the pathogenesis of axSpA.

ARTHRITIS RESEARCH & THERAPY (2022)

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Article Rheumatology

Which factors are associated with bone marrow oedema suspicious of axial spondyloarthritis as detected by MRI in the sacroiliac joints and the spine in the general population?

Xenofon Baraliakos et al.

Summary: This population-based cohort study identified factors associated with MRI lesions suggestive of axial spondyloarthritis (axSpA) in individuals aged <45 years. The presence and extension of bone marrow edema (BME) in spinal and sacroiliac joints (SIJ) were strongly associated with factors such as delivery during the last year, HLA-B27 positivity, body mass index, and back pain. These findings support the hypothesis of mechanical strain contributing to BME in the general population aged <45 years and suggest that HLA-B27 positivity may play a role in severity rather than susceptibility to SIJ-BME.

ANNALS OF THE RHEUMATIC DISEASES (2021)

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Article Multidisciplinary Sciences

Impact of age, sex, and joint form on degenerative lesions of the sacroiliac joints on CT in the normal population

Katharina Ziegeler et al.

Summary: The study found that degenerative changes in the sacroiliac joints are more common in women, with a higher likelihood of developing osteophytes. Atypical joint forms are more prevalent in women, which was confirmed in the study.

SCIENTIFIC REPORTS (2021)

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Article Rheumatology