Journal
NATURE REVIEWS NEUROSCIENCE
Volume 17, Issue 8, Pages 485-496Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrn.2016.68
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Funding
- Xi'an Jiaotong University, China
- EJLB Fondation-CIHR (Canadian Institutes of Health Research)
- Canada Research Chair
- Canadian Institute for Health Research [MOP-258523]
- Natural Sciences and Engineering Research Council of Canada [RGPIN 402555]
- Azrieli Neurodevelopmental Research Program
- Brain Canada
- National Honor Scientist Program (NRF) in Korea [2012R1A3A1050385]
- UK Medical Research Council
- UK Biotechnology and Biological Sciences Research Council
- European Research Council
- MRC [MR/K023098/1] Funding Source: UKRI
- Medical Research Council [MR/K023098/1] Funding Source: researchfish
- National Research Foundation of Korea [2012R1A3A1050385] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The anterior cingulate cortex (ACC) is activated in both acute and chronic pain. In this Review, we discuss increasing evidence from rodent studies that ACC activation contributes to chronic pain states and describe several forms of synaptic plasticity that may underlie this effect. In particular, one form of long-term potentiation (LTP) in the ACC, which is triggered by the activation of NMDA receptors and expressed by an increase in AMPA-receptor function, sustains the affective component of the pain state. Another form of LTP in the ACC, which is triggered by the activation of kainate receptors and expressed by an increase in glutamate release, may contribute to pain-related anxiety.
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