Journal
INTEGRATIVE MEDICINE RESEARCH
Volume 12, Issue 3, Pages -Publisher
ELSEVIER
DOI: 10.1016/j.imr.2023.100968
Keywords
Alzheimer's disease; Curcumin; Inflammation; Neurological disorders; Parkinson's disease
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Curcumin has pleiotropic immunomodulatory functions and neuroprotective properties, and can suppress neuroinflammation by modulating diverse signaling pathways.
Background: Despite the extensive research in recent years, the current treatment modalities for neurological disorders are suboptimal. Curcumin, a polyphenol found in Curcuma genus, has been shown to mitigate the pathophysiology and clinical sequalae involved in neuroinflammation and neurodegenerative diseases. Methods: We searched PubMed database for relevant publications on curcumin and its uses in treating neuro-logical diseases. We also reviewed relevant clinical trials which appeared on searching PubMed database using 'Curcumin and clinical trials'. Results: This review details the pleiotropic immunomodulatory functions and neuroprotective properties of cur -cumin, its derivatives and formulations in various preclinical and clinical investigations. The effects of curcumin on neurodegenerative diseases such as Alzheimer's disease (AD), amyotrophic lateral sclerosis (ALS), brain tu-mors, epilepsy, Huntington's disorder (HD), ischemia, Parkinson's disease (PD), multiple sclerosis (MS), and trau-matic brain injury (TBI) with a major focus on associated signalling pathways have been thoroughly discussed. Conclusion: This review demonstrates curcumin can suppress spinal neuroinflammation by modulating diverse astroglia mediated cascades, ensuring the treatment of neurological disorders.
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