Cardiac tissue engineering for the treatment of hypoplastic left heart syndrome (HLHS)

Hypoplastic left heart syndrome (HLHS) is a deadly congenital heart disease that arises when the left ventricle and outflow tract fail to develop appropriately, inhibiting the adequate perfusion of the rest of the body. Historically, this disease has been treated via a series of surgeries that allows the heart to use a single ventricle. These surgeries are often a palliative measure, and heart transplantation is the only definitive therapy that exists for this condition. It has been hypothesized that stem cell-based regenerative therapies could have a role in promoting cardiac tissue regeneration in HLHS patients who are undergoing palliative surgery. Several clinical trials have demonstrated that introducing pluripotent cells into the heart is safe, feasible, and capable of improving right ventricular ejection fraction (RVEF). However, while these approaches show great promise, there is still room for development. There is a substantial body of pre-clinical work that is focused on generating increasingly large and complex pieces of cardiac tissue in the form of cardiac patches, with the idea that these could be used to rebuild and strengthen the heart in a robust and long-lasting manner. In total, stem cell-based therapies have much to offer when it comes to improving the treatment of HLHS.

Automated summary

Hypoplastic left heart syndrome (HLHS) is a deadly congenital heart disease that can be treated with stem cell-based regenerative therapies. These therapies have shown promise in improving heart function in HLHS patients undergoing palliative surgery. However, further development and research are needed, particularly in the generation of larger and more complex cardiac tissue patches for robust and long-lasting heart rebuilding. Overall, stem cell-based therapies have great potential in improving the treatment of HLHS.