Journal
CHEMPHOTOCHEM
Volume -, Issue -, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cptc.202300159
Keywords
DNA recognition; cyclization; photoisomerization; benzo[c]quinolizium; circular dichroism
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The photocyclization reaction of sterically demanding styrylpyridine derivatives was investigated, and the interaction with DNA was found to depend on the DNA type. Specifically, this ligand preferentially binds to DNA containing abasic sites, and the complex formation can be achieved by irradiation of the styrylpyridine substrate.
The photocyclization reaction of sterically demanding styrylpyridine derivatives was investigated and shown to depend on the type of substituent. With this method, a 2,2-diphenyl-1,3-benzodioxolo-annelated benzo[c]quinolizinium was synthesized, and its association with regular and abasic site-containing DNA (AP-DNA) was investigated by absorption, fluorescence, circular and linear dichroism spectroscopy. Specifically, this ligand binds preferentially to AP-DNA relative to regular duplex DNA, and the AP-DNA/ligand complex is formed in situ upon irradiation of the styrylpyridine substrate in the presence of the DNA.
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