Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 5, Pages 280-292Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.27
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Funding
- US National Institutes of Health (NIH) [R01 CA083688, R01 CA132740, P01 CA080111]
- Spanish Ministry of Economy and Competitiveness [SAF2012-38215, SAF2014-57791-REDC, BFU2014-52125-REDT]
- Comunidad de Madrid [S2010/BMD-2470]
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The roles of cyclins and their catalytic partners, the cyclin-dependent kinases (CDKs), as core components of the machinery that drives cell cycle progression are well established. Increasing evidence indicates that mammalian cyclins and CDKs also carry out important functions in other cellular processes, such as transcription, DNA damage repair, control of cell death, differentiation, the immune response and metabolism. Some of these non-canonical functions are performed by cyclins or CDKs, independently of their respective cell cycle partners, suggesting that there was a substantial divergence in the functions of these proteins during evolution.
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