Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 10, Pages 611-625Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.87
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Funding
- Swedish Science Council
- Swedish Cancer Foundation
- World-wide Cancer Research
- Knut and Alice Wallenberg Foundation
- US National Institutes of Health (NIH) [R01 HL053793, HL084619, P01 HL107205]
- Wenner-Gren foundation grant
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Vascular endothelial growth factors (VEGFs) and their receptors (VEGFRs) are uniquely required to balance the formation of new blood vessels with the maintenance and remodelling of existing ones, during development and in adult tissues. Recent advances have greatly expanded our understanding of the tight and multi-level regulation of VEGFR2 signalling, which is the primary focus of this Review. Important insights have been gained into the regulatory roles of VEGFR-interacting proteins (such as neuropilins, proteoglycans, integrins and protein tyrosine phosphatases); the dynamics of VEGFR2 endocytosis, trafficking and signalling; and the crosstalk between VEGF-induced signalling and other endothelial signalling cascades. A clear understanding of this multifaceted signalling web is key to successful therapeutic suppression or stimulation of vascular growth.
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