Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 7, Pages 413-425Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.24
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Funding
- Cholangiocarcinoma Foundation
- US National Institutes of Health (NIH) [DK104196, CA169123]
- Penn Institute for Regenerative Medicine
- Biesecker Pediatric Liver Center
- Abramson Family Cancer Research Institute
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Biologists have long been intrigued by the possibility that cells can change their identity, a phenomenon known as cellular plasticity. The discovery that terminally differentiated cells can be experimentally coaxed to become pluripotent has invigorated the field, and recent studies have demonstrated that changes in cell identity are not limited to the laboratory. Specifically, certain adult cells retain the capacity to de-differentiate or transdifferentiate under physiological conditions, as part of an organ's normal injury response. Recent studies have highlighted the extent to which cell plasticity contributes to tissue homeostasis, findings that have implications for cell-based therapy.
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