Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 12, Pages 743-755Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.104
Keywords
-
Categories
Funding
- Ludwig Institute for Cancer Research, La Jolla, California, USA
- US National Institutes of Health (NIH) [U54DK107977, U54 HG006997, R01 ES024984]
- NIH [T32 GM008666]
Ask authors/readers for more resources
Chromosomes of eukaryotes adopt highly dynamic and complex hierarchical structures in the nucleus. The three-dimensional (3D) organization of chromosomes profoundly affects DNA replication, transcription and the repair of DNA damage. Thus, a thorough understanding of nuclear architecture is fundamental to the study of nuclear processes in eukaryotic cells. Recent years have seen rapid proliferation of technologies to investigate genome organization and function. Here, we review experimental and computational methodologies for 3D genome analysis, with special focus on recent advances in high-throughput chromatin conformation capture (3C) techniques and data analysis.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available