Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 357, Issue 14-15, Pages 3069-3075Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201500510
Keywords
2H-azirines; cascade cyclization; copper enynes; spirocyclic skeleton
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Funding
- National Natural Science Foundation [NSF 21272101, 21472074, 21472073]
- Fundamental Research Funds for Central Universities [lzujbky-2014-243]
- 111 Project [J1103307]
- Program for Changjiang Scholars, innovative Research Team in University [IRT1138]
- Cuiying Student Innovation Fund of Lanzhou University [CYCXJJ-2015003]
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A method for the synthesis of trifluoromethyl CF3-substituted spirocyclic compounds containing with a unique quaternary carbon center from readily available starting materials has been developed. The reaction provides a facile access to 2H-azirines via cascade cyclization. These compounds constitute a new class of functionalized synthetic intermediates, which can be used for the synthesis of various nitrogen-containing heterocycles and biologically active CF3-containing compounds.
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