Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 10, Pages 643-658Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.76
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Funding
- European Research Council (ERC)
- Worldwide Cancer Research Association
- Foundation La Marato
- Spanish Ministry of Economy and Development
- Foundation Vencer el Cancer (Beat Cancer)
- Government of Cataluna
- Foundation Botin
- Institute for Research in Biomedicine (IRB-Barcelona)
- Marie Curie EU COFUND postdoctoral fellowship
- MINECO (Government of Spain)
- ICREA Funding Source: Custom
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Mammalian embryonic development is a tightly regulated process that, from a single zygote, produces a large number of cell types with hugely divergent functions. Distinct cellular differentiation programmes are facilitated by tight transcriptional and epigenetic regulation. However, the contribution of epigenetic regulation to tissue homeostasis after the completion of development is less well understood. In this Review, we explore the effects of epigenetic dysregulation on adult stem cell function. We conclude that, depending on the tissue type and the epigenetic regulator affected, the consequences range from negligible to stem cell malfunction and disruption of tissue homeostasis, which may predispose to diseases such as cancer.
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