Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 11, Pages 679-690Publisher
NATURE PORTFOLIO
DOI: 10.1038/nrm.2016.93
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Funding
- National Institute on Aging
- National Institutes of Health
- Paul F. Glenn Foundation for Medical Research
- Ovaxon
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The sirtuins (SIRT1-7) are a family of nicotinamide adenine dinucleotide (NAD(+))-dependent deacylases with remarkable abilities to prevent diseases and even reverse aspects of ageing. Mice engineered to express additional copies of SIRT1 or SIRT6, or treated with sirtuin-activating compounds (STACs) such as resveratrol and SRT2104 or with NAD(+) precursors, have improved organ function, physical endurance, disease resistance and longevity. Trials in non-human primates and in humans have indicated that STACs may be safe and effective in treating inflammatory and metabolic disorders, among others. These advances have demonstrated that it is possible to rationally design molecules that can alleviate multiple diseases and possibly extend lifespan in humans.
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