Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 18, Issue 1, Pages 56-67Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.127
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Funding
- US National Institutes of Health [U01 HL100395, 5R01HL091724]
- Canadian Institutes of Health Research grant [MOP126117]
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Human pluripotent stem cells (hPSCs) provide an unparalleled opportunity to establish in vitro differentiation models that will transform our approach to the study of human development. In the case of the blood system, these models will enable investigation of the earliest stages of human embryonic haematopoiesis that was previously not possible. In addition, they will provide platforms for studying the origins of human blood cell diseases and for generating de novo haematopoietic stem and progenitor cell populations for cell-based regenerative therapies.
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