Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 3, Pages 155-169Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2015.28
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Funding
- European Research Council (ERC) [StG-2011-281906]
- ERC [PoC-2015-692945]
- New York Stem Cell Foundation (NYSCF)
- Flight Attendant Medical Research Institute (FAMRI)
- Kimmel Innovator Research Award
- Moross Cancer Institute
- Israel Science Foundation - Natural Science Foundation of China programme
- Morasha Biomed programme
- ICORE programme
- ICRF Foundation
- MINERVA fund
- Helen and Martin Kimmel Institute for Stem Cell research
- Benoziyo Endowment fund
- David and Fela Shapell Family Foundation INCPM Fund for Preclinical Studies
- HFSPO research grant
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The molecular mechanisms and signalling pathways that regulate the in vitro preservation of distinct pluripotent stem cell configurations, and their induction in somatic cells by direct reprogramming, constitute a highly exciting area of research. In this Review, we integrate recent discoveries related to isolating unique naive and primed pluripotent stem cell states with altered functional and molecular characteristics, and from different species. We provide an overview of the pathways underlying pluripotent state transitions and interconversion in vitro and in vivo. We conclude by highlighting unresolved key questions, future directions and potential novel applications of such dynamic pluripotent cell states.
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