Journal
NATURE REVIEWS MOLECULAR CELL BIOLOGY
Volume 17, Issue 7, Pages 451-459Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nrm.2016.25
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Funding
- US National Institutes of Health (NIH) [R01 GM114368, PO1 A1043376-02S1]
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Metabolomics, which is the profiling of metabolites in biofluids, cells and tissues, is routinely applied as a tool for biomarker discovery. Owing to innovative developments in informatics and analytical technologies, and the integration of orthogonal biological approaches, it is now possible to expand metabolomic analyses to understand the systems-level effects of metabolites. Moreover, because of the inherent sensitivity of metabolomics, subtle alterations in biological pathways can be detected to provide insight into the mechanisms that underlie various physiological conditions and aberrant processes, including diseases.
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